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Medical and surgical treatment of inflammatory bowel disease

Publicerad 11 februari 2022

Medical and surgical treatment of inflammatory bowel disease Anders Forss, Karolinska Institutet, Stockholm 2022

Inflammatory bowel disease (IBD), with its two main entities Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic and relapsing inflammatory condition affecting the entire gastrointestinal tract. IBD is associated with reduced health-related quality of life, substantial loss of work productivity and increased morbidity. In Sweden alone, around 70 000 persons are estimated to be affected by IBD. Treatment includes both medical and surgical therapy. In case of failure or intolerance to conventional medical therapies, remaining treatment options are surgery or newer medical therapies such as biological agents. However, a sizeable number of patients do not respond or lose response to a certain biological agent, hence there is still a need to expand the knowledge about therapeutic options in IBD. This thesis therefore aimed to explored real-world clinical outcomes of a recent biological therapy. Using registered-based data, the thesis also investigated epidemiological aspects of IBD including the validity of IBD-related surgical procedure codes and the incidence of IBD in Sweden.

Thesis Medical and surgical treatment of inflammatory bowel Anders Forss 2022 (pdf)